Mnemonics: Angioedema

Author: V. Dimov, M.D., Allergist/Immunologist and Assistant Professor at University of Chicago
Reviewer: S. Randhawa, M.D., Allergist/Immunologist and Assistant Professor at NSU


Autosomal dominant
Androgens for prophylaxis

HAE mnemonic

C1 inhibitor is low
C1 q level is normal
11 chromosome
11 years is the mean age of onset
11 years before the diagnosis is made, on average

Treatment of HAE

Recombinant human C1 inhibitor from mammary secretions of trangenic rabbit

Angioedema (AE) can be allergic or non-allergic.

There are 5 types of non-allergic angioedema (AE):

- acquired AE
- hereditary AE (HAE)
- ACE-inhibitor induced AE
- idiopathic AE, can occur with chronic urticaria
- pseudoallergic AE, e.g. reaction to NSAIDs

There are 3 types of HAE that are differentiated by C4 and C1-INH levels

- type I HAE - low C4, low C1-INH function, low C1-INH antigen level
- type II HAE - low C4, low C1-INH function, normal C1-INH antigen level
- type III HAE - all normal

Treatment of acute HAE attacks

- C1-INH, 20 units/kg, IV infusion
- Icatibant, 30 mg SC, bradykinin B2 receptor antagonist
- Ecallantide, 30 mg SC, kallikrein receptor antagonist

Prophylaxis of HAE attacks

- C1-INH, 1,000 units, IV infusion every 3-4 days
- attenuated androgen, e.g. danocrine 200 mg PO TID

Angioedema (AE) Classification (click to enlarge the image):


New Directions in the Treatment of Angioedema. Medscape, 2012.
International consensus on hereditary and acquired angioedema. Annals, 2012.

Published: 02/07/2008
Updated: 12/12/2012

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