Author: V. Dimov, M.D.
Reviewer: S. Randhawa, M.D.
Classification of adverse reactions to drugs: SOAP III
Classification of adverse reactions to drugs: "SOAP III" mnemonic (click to enlarge the image).
Rule of 10s in ADR
10% of patients develop ADR
10% of these are due to allergy
10% of these lead to anaphylaxis
10 % of these lead to death
Manifestations of beta-lactams hypersensitivity: MAUS
Maculopapular exanthema, 19%
Anaphylaxis without shock, 19%
Shock, anaphylactic shock, 17%
References: Clinical presentation and time course in hypersensitivity reactions to β-lactams. Allergy, 2007.
Hypersensitivity reactions to beta-lactam antibiotics: MAUS mnemonic 20-20-40-20%. Click here to enlarge the image.
Samter's triad include asthma, aspirin sensitivity, and nasal/ethmoidal polyposis:
Sensitivity to aspirin
Toxic epidermal necrosis (TEN)
Thirty percent of the skin (SJS less than 10%)
Management of adverse drug reactions: PAD
Premedication with antihistamines and steroids
Multiple choice questions
Chapter 57: Drug Allergy. Allergy and Immunology Review Corner: Chapter 57 of Pediatric Allergy: Principles & Practices, edited by Donald Y.M. Leung, et al.