Author: V. Dimov, M.D., Allergist/Immunologist and Assistant Professor at University of Chicago
Reviewer: S. Randhawa, M.D., Allergist/Immunologist and Assistant Professor at LSU (Shreveport) Department of Allergy and Immunology
The curved leucine-rich repeat region of toll-like receptors, represented here by TLR3. Image source: Wikipedia.
Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations. Image source: Wikipedia.
TB and other mycobacteria
TLR4 (for LPS)
Nucleotide motifs - CpG
Three is "Free" of MyD88
What are the intracellular TLRs?
TLR 3, 7, 8, and 9 are in the intracellular compartment and detect nucleic acids.
What is MyD88?
MyD88 is an adapter protein that plays a role in TLR signaling. MyD88 is involved in all TLR-signaling pathways except TLR 3.
Nickel allergy tracked to a single receptor - Toll-like receptor 4 (TLR4) http://goo.gl/PZic