Reviewer: S. Randhawa, M.D., Allergist/Immunologist and Assistant Professor at LSU (Shreveport) Department of Allergy and Immunology
Phagocyte immunodeficiencies (click to enlarge the image):
Leukocyte adhesion deficiency (abbreviated LAD) is an immunodeficiency resulting in recurrent infections.
There are several types:
LAD I - beta 2-integrin family is deficient or defective.
LAD II - fucosylated carbohydrate ligands for selectins are absent, fewer infections but more developmental delay as compared to LAD I.
LAD III - activation of all beta–integrins (1, 2, and 3) is defective.
Leukocyte adhesion deficiency II (LAD2 ) is characterized by which of the following?
(A) X-linked inheritance
(D) severe mental retardation
(E) autosomal recessive inheritance
(F) CD18 defect
(G) Sialyl LewisX-related defect
Answers: D, E, G. LAD1 is related to CD18 defect (not LAD2).
Leukocyte adhesion deficiency type I (LAD I)
Leukocyte adhesion deficiency type II (LAD II)
Leukocyte adhesion deficiency type III (LAD III)
ABAI Board Review, 2008.
Leukocyte adhesion deficiency. Wikipedia.
Sialyl Lewis X. Wikipedia.