Author: V. Dimov, M.D., Fellow, Creighton University Division of Allergy & Immunology
Reviewer: S. Randhawa, M.D., Fellow, LSU (Shreveport) Department of Allergy & Immunology
Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion. It is normally produced during fetal development and its production stops before birth. CEA not present in the blood of healthy adults.
CEA is also known as CD66. It belongs to the immunoglobulin superfamily.
Overview of adhesion molecules, 3 groups remembered by the mnemonic SIS.
Adhesion molecules, 3 groups = SIS:
CEA is elevated in individuals with colorectal carcinoma and gastric carcinoma.
Arcitumomab is a murine (mouse) monoclonal antibody which recognizes carcinoembryonic antigen (CEA).
Ig Superfamily = cell adhesion molecules (CAM)
VCAM (vascular cell adhesion molecule)
ICAM (intercellular adhesion molecule)
PECAM (platelet-endothelial cell adhesion molecule)
Intercellular adhesion molecule 2 (ICAM 2). Image source: Wikipedia.
Carcinoembryonic antigen. Wikipedia.
Cluster of differentiation (CD) of leukocytes