Author: V. Dimov, M.D., Allergist/Immunologist and Assistant Professor at University of Chicago
Reviewer: S. Randhawa, M.D., Allergist/Immunologist and Assistant Professor at LSU (Shreveport) Department of Allergy and Immunology
TGF-β was discovered as a tumor product that promoted the survival of cells.
Some regulatory T cells produce TGF-β, and the same cells may also produce IL-10, which also has immunosuppressive activities.
TGF-β inhibits the proliferation and effector functions of T cells and the activation of macrophages. Acts on neutrophils and endothelial cells to counteract the effects of pro-inflammatory cytokines.
TGF-β stimulates production of IgA by inducing B cells to switch to this isotype.
Cellular and Molecular Immunology, Abbas et al, 2009.