Transforming Growth Factor-β (TFG-β)

Author: V. Dimov, M.D., Allergist/Immunologist and Assistant Professor at University of Chicago
Reviewer: S. Randhawa, M.D., Allergist/Immunologist and Assistant Professor at LSU (Shreveport) Department of Allergy and Immunology

TGF-β was discovered as a tumor product that promoted the survival of cells.

Some regulatory T cells produce TGF-β, and the same cells may also produce IL-10, which also has immunosuppressive activities.

TGF-β inhibits the proliferation and effector functions of T cells and the activation of macrophages. Acts on neutrophils and endothelial cells to counteract the effects of pro-inflammatory cytokines.

TGF-β stimulates production of IgA by inducing B cells to switch to this isotype.


Cellular and Molecular Immunology, Abbas et al, 2009.

Published: 04/09/2010
Updated: 04/09/2010

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