Reviewer: S. Randhawa, M.D., Allergist/Immunologist and Assistant Professor at LSU (Shreveport) Department of Allergy and Immunology
Positive ELR (glutamic acid-leucine-arginine) chemokine CXC
1 or I
Interferon-induced T migration
Chemokines that guide T and B cell migration within lymph nodes
CXCL13 (BCA-1) - binds to CXCR5 - causes B cell migration into follicles
CCL19 (MIP-3β/ELC) and CCL21 (SLC) - both bind to CCR7 - cause T cell and dendritic cell migration into parafollicular zones of lymph nodes
CXCL13 binds to CXCR5 - causes B cell migration into follicles
1 + 3 = 4, 5 (binds to CXCR5)
CCL19 and CCL21 bind to CCR7 - cause T cell cell migration into parafollicular zones of lymph nodes
9 - 2 = 7 (bind to CCR7)
What chemokine attracts naïve B cells to lymph nodes?
CXCR5. CXCL13 binds to CXCR5.
What chemokine attracts naïve T cells to lymph nodes?
CCR7. CCL19 and CCL21 bind to CCR7.