Author: V. Dimov, M.D., Allergist/Immunologist and Assistant Professor at University of Chicago
Reviewer: S. Randhawa, M.D., Allergist/Immunologist and Assistant Professor at LSU (Shreveport) Department of Allergy and Immunology
Source: CD4 T cells.
Receptors: Type I cytokine receptor family. Signal transduction involves Jak-STAT.
Erythropoietin (Epo) is produced in the kidney in response to low oxygen tension. Epo works through a type I cytokine receptor that signals through Jak2-STAT5.
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IL-3 effects: IL-3 promotes the growth and development of mast cells from bone marrow.
IL-3 is a basophil differentiating cytokine vs. stem cell factor (c-Kit ligand) which is a mast cell growth factor.