Reviewer: S. Randhawa, M.D., Allergist/Immunologist and Assistant Professor at LSU (Shreveport) Department of Allergy and Immunology
Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor signalling. Syk is the ZAP-70 analog in B cells.
However, recent reports indicate that SYK also mediates other, unexpectedly diverse biological functions, including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. SYK is activated by C-type lectins and integrins, and activates new targets, including the CARD9–BCL-10–MALT1 pathway and the NLRP3 inflammasome.
There is an evolutionarily ancient origin of SYK-mediated signalling. Moreover, SYK has a crucial role in autoimmune diseases and haematological malignancies.
The SYK tyrosine kinase is an evolutionarily ancient crucial player in diverse biological functions.
T cell activation involves all of the following steps EXCEPT:
A. RAS- MAPK pathway
B. activation of Syk
C. activation of NFAT
D. activation of Protein Kinase C
Answer: B. Syk is part of the B cell activation. ZAP-70 is its equivalent in T cells.
The SYK tyrosine kinase: a crucial player in diverse biological functions. Nature Reviews Immunology 10, 387-402 | doi:10.1038/nri2765